The effect of the CYP 2 C 8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide
نویسندگان
چکیده
Department of Pharmacology, Clinical Pharmacology, University of Cologne, Germany (D.T.S., U.F., D.F., O.D., A.J., J.S.); Institute of Medical Statistics, Informatics and Epidemiology University of Cologne, Germany (M.H.); Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zürich, Switzerland (A.J.); Department of Pharmacology of Natural Products and Clinical Pharmacology, University of Ulm, Germany (J.S.) DMD Fast Forward. Published on January 26, 2011 as doi:10.1124/dmd.110.036921
منابع مشابه
Effect of the CYP2C8 genotype on the pharmacokinetics and pharmacodynamics of repaglinide.
The pharmacokinetics of repaglinide shows pronounced interindividual variability, for which several reasons have been considered, including interactions with drugs inhibiting CYP2C8 and CYP2C8 genetic polymorphism. However, existing data on the role of genetic polymorphisms in repaglinide disposition are not fully consistent. We studied the effect of CYP2C8*3 on the pharmacokinetics and pharmac...
متن کاملPharmacokinetic Interactions of Pioglitazone
........................................................................................................................................................ INTRODUCTION........................................................................................................................................... REVIEW OF THE LITERATURE.......................................................................
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
متن کاملEvaluation of pharmacokinetic and pharmacodynamic interaction between repaglinide and atazanavir in healthy, diabetic and hepatic impaired rats: possible inhibition of CYP3A, OATP, and P-glycoprotein transporters
The metabolic syndrome in HIV infected patients is particularly associated with the use protease inhibitors. Atazanavir is an inhibitor of the cytochrome P 450 (CYP) system, in particular CYP3A4 and CYP2C9 which can affect the metabolism of several drugs. To treat metabolic syndrome in HIV patients repaglinide is used and it is a short acting insulin secretagogues undergoing metabolism with CYP...
متن کاملAn Investigation into the Role of P-Glycoprotein in the Intestinal Absorption of Repaglinide: Assessed by Everted Gut Sac and Caco-2 Cell Line
The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability. In-vitro intestinal absorption models, the everted gut sac, and Caco-2 cell line, were used to study the possible role of P-gp in intestinal transport of REG. In the everted gut sacs, apparent permeability coefficients showed cargo concentra...
متن کامل